During WWII several murders occur at a convalescent home where Dr. Watson has volunteered his services. He summons Holmes for help and the master detective proceeds to solve the crime from a long list of suspects including the owners of the home, the staff and the patients recovering there.

Sherlock Holmes takes on a case that the press has dubbed the pajama suicides. Eminent men are going to bed in the safety of their own homes, with everything seemingly being normal, only to commit suicide in the night. Holmes fakes his own death in the hopes of giving him a freer hand in the investigation and is convinced that a woman, a female Moriarty as he describes her, is behind the deaths. The dead men were all eminent and very wealthy. He impersonates a wealthy retired Indian military officer in the hope of drawing out the woman and he soon meets Adrea Spedding but she quickly sees through his disguise and proves herself to be the challenge Holmes predicted she would be. She is a worthy adversary and soon traps him setting him up in a carnival shooting gallery that seems to assure his death.